Syncytia formation during SARS-CoV-2 lung infection: a ... - Nature
2021年5月12日 · The new data obtained by Sun et al. provide critical information for understanding syncytia through deciphering the structure basis required for SARS-CoV-2 …
Syncytia formation by SARS‐CoV‐2‐infected cells - PMC
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms regulating …
Syncytia formation during SARS-CoV-2 lung infection: a …
Sun et al. found that a type of CD45 positive cell structure presents in the syncytia of the COVID-19 patients. This could be a cell-in-cell structure. When human peripheral blood mononuclear …
Syncytia formation by SARS-CoV-2-infected cells - PubMed
2020年12月1日 · Severe cases of COVID-19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
2021年4月7日 · Here we show that the lungs of patients with COVID-19 contain infected pneumocytes with abnormal morphology and frequent multinucleation. The generation of …
High-throughput screening of genetic and cellular drivers of
2023年11月23日 · Mapping mutations and discovering cellular determinants that cause the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to induce infected …
Ultrastructural study confirms the formation of single and …
2023年5月19日 · SARS-CoV-2 was reported to induce cell fusions to form multinuclear syncytia that might facilitate viral replication, dissemination, immune evasion, and inflammatory …
Differences in syncytia formation by SARS-CoV-2 variants modify …
2023年12月26日 · Critically, syncytia formation via the highly fusogenic Delta spike promotes cellular senescence and extracellular cytokine release in a TP53-dependent manner. We …
The Mechanism and Consequences of SARS-CoV-2 Spike …
We summarize the clinical evidence for coronavirus-induced syncytia formation, examine the molecular determinants of S protein-mediated fusion, and discuss the antiviral innate immunity …
Syncytia formation by SARS‐CoV‐2‐infected cells
2020年11月4日 · Our results show that SARS‐CoV‐2 pathological effects are modulated by cellular proteins that either inhibit or facilitate syncytia formation. Cells infected with …