A chemogenetic screen reveals that Trpv1-expressing neurons
Using genetically deficient mice, we found that the neuropeptide calcitonin gene–related peptide (CGRP) and its receptor RAMP1 were required for this neuroimmune interaction. This work provides a framework to reveal functional neuroimmune interactions in the gut.
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 ... - Cell …
2022年10月14日 · Pain sensory neurons induce mucus release from nearby intestinal goblet cells via a CGRP-Ramp1 axis in response to commensal and dietary cues to orchestrate gut mucosal protection.
Nociceptor sensory neurons suppress neutrophil and γδ T cell
2018年3月5日 · Vagal ganglia TRPV1 + afferents mediated immunosuppression through release of the neuropeptide calcitonin gene–related peptide (CGRP). Targeting neuroimmunological signaling may be an effective...
CGRP sensory neurons promote tissue healing via neutrophils and ...
2024年3月27日 · CGRP acts via receptor activity-modifying protein 1 (RAMP1) on neutrophils, monocytes and macrophages to inhibit recruitment, accelerate death, enhance efferocytosis and polarize macrophages...
Neuronal TRPV1-CGRP axis regulates bone defect repair through …
2023年9月1日 · In vitro, results revealed that TRPV1 function in DRG neurons contributed essentially to the regulation of osteoblast physiology through affecting the production and secretion of CGRP. The capsaicin-activated neuronal TRPV1-CGRP axis could enhance the proliferation, migration and differentiation of osteoblasts (p < 0.05).
Lung-innervating nociceptor sensory neurons promote …
2024年9月6日 · To understand how TRPV1 + nociceptors promote CRKP transmigration, we analyzed CGRP levels in BALF samples from Trpv1 DTA and control mice. We observed significantly reduced levels of CGRP in the BALF in Trpv1 DTA mice compared to the levels in control mice at both baseline and with infection .
Nociceptor neurons affect cancer immunosurveillance - Nature
2022年11月2日 · Genetic ablation of the TRPV1 lineage, local pharmacological silencing of nociceptors and antagonism of the CGRP receptor RAMP1 all reduced the exhaustion of tumour-infiltrating leukocytes...
Innervation of nociceptor neurons in the spleen promotes …
2024年6月6日 · Nociceptors from left T8–T13 dorsal root ganglia innervate the spleen along blood vessels and signal to B cells via a CGRP-CALCRL/RAMP1 axis to promote humoral immune responses and host defense.
29 TRPV1-Expressing Sensory Neuron Stimulation-based Model …
2022年5月1日 · We found prominent CGRP-immunoreactive sensory nerve presence innervating human HNSCC tumor tissue, which positively correlated to patient- reported pain (r2=0.357). Furthermore, human HNSCC cell lines expressed 3-fold more CGRP receptor, RAMP1, compared to a non- tumorigenic keratinocyte cell line.
Innervation of nociceptor neurons in the spleen promotes …
2024年5月20日 · Our findings demonstrate a specific dorsal root ganglia (DRG)-spleen sensory neural connection that promotes humoral immune responses via a CGRP-CALCRL/RAMP1 axis. Thus, targeting the splenic nociceptive nervous system could be a promising approach to enhance antigen-induced protection or thwart B cell-associated autoimmune diseases.