Double-Faced Immunological Effects of CDK4/6 Inhibitors on
2024年10月29日 · Cyclin-dependent kinases (CDKs) are generally involved in the progression of cell cycle and cell division in normal cells, while abnormal activations of CDKs are deemed to be a driving force for accelerating cell proliferation and tumorigenesis. Therefore, CDKs have become ideal therapeutic targets for cancer treatment. The U.S FDA has approved three CDK4/6 …
CDK4/6 inhibition initiates cell cycle arrest by nuclear ... - Nature
2024年10月26日 · CDK4/6 inhibitors predominantly induce cell cycle arrest in the G1-phase, followed by a senescence-like phenotype at later stages. Also, alteration in cellular metabolism and enhancement of cancer ...
Mitochondrial fatty acid oxidation drives senescence
2024年10月25日 · Cellular senescence is a stress-induced irreversible cell cycle arrest that is typically accompanied by the expression of the cyclin-dependent kinase (CDK) inhibitor p16 INK4a (hereafter referred to as p16) (1–5).Many senescence-inducing stresses, such as telomere shortening and oncogene activation, produce DNA damage, mainly double-strand breaks, and …
Immunomodulation by anticancer cell cycle inhibitors
2020年4月28日 · In this Review, we discuss the ability of anticancer cell cycle inhibitors to modulate various immune functions in support of effective antitumour immunity.
Cell cycle control in cancer | Nature Reviews Molecular Cell Biology
2021年9月10日 · This Review discusses our current understanding of cell cycle regulation, the functions of cell cycle checkpoints and how disruption of these finely tuned mechanisms is associated with...
The pathophysiology of the cell cycle in cancer and treatment ...
2023年11月1日 · To combat the dysregulation of the cell cycle in cancer, various therapeutic strategies have been developed, including CDK inhibitors, cyclin inhibitors, and checkpoint activators. These treatments can halt the progression of the cell cycle, promote DNA repair, and induce cell death in cancer cells.
CDK inhibitors in cancer therapy, an overview of recent …
CDK inhibitors have been studied since the 1990s. The first generation of CDK inhibitors are pan-CDK inhibitors, including Flavopiridol and Roscovitine, etc. The main function of these inhibitors is to block cell cycle and inhibit cell proliferation by inhibiting the CDK enzyme activity.
Immunomodulation by anticancer cell cycle inhibitors - PubMed
Accumulating preclinical and clinical evidence indicates that the anticancer activity of CDK4/CDK6 inhibitors results not only from their ability to block the cell cycle in malignant cells but also from a range of immunostimulatory effects.
New Insights into CDK Regulators: Novel Opportunities for ... - Cell …
2021年3月3日 · Recent research studies confirmed the existence of a third class of cyclin-dependent kinase (CDK) inhibitors, besides CDK-interacting protein/kinase inhibitory protein (CIP/KIP) and inhibitor of kinase (INK) families, called ribosomal protein inhibiting CDKs (RPICs).
Cell Cycle Regulation Meets Tumor Immunosuppression
2020年8月13日 · Recent studies indicate that enhanced cell cycle activity in cancer cells suppresses antitumor immunity. Herein we discuss potential mechanisms by which cell cycle programs intrinsic to tumor cells are coupled to immune behavior, with consequences for immunotherapy.
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