Wnt signaling pathway - Wikipedia
The three best characterized Wnt signaling pathways are the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. As their names suggest, these pathways belong to one of two categories: canonical or noncanonical.
Wnt信号通路浅谈 - 知乎 - 知乎专栏
在胚胎发育中，Wnt基因调控的重要信号传导系统即为Wnt通路。 Wnt可以分为 经典Wnt途径 （Canonical pathway）， 非典型平面细胞极性途径 （Planar cell polarity pathway），和 非经典Wnt信号/ 钙通路 （Wnt/Ca2+ pathway）,三条通路都需要经过 Frizzled ，这是 分泌型糖蛋白Wnt …
Wnt/β-catenin signalling: function, biological mechanisms, …
2022年1月3日 · The canonical Wnt signalling pathway is a therapeutic target for many non-cancer diseases, usually by inhibiting Wnt signal and β-catenin activity.
Wnt/β-catenin signaling: components, mechanisms, and diseases
Signaling by the Wnt family of secreted glycolipoproteins via the transcription co-activator β-catenin controls embryonic development and adult homeostasis. Here we review recent progresses in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists and antagonists and their interactions with Wnt receptors.
Wnt signal transduction pathways - PMC - PubMed Central (PMC)
The canonical Wnt signaling plays a pivotal role in cell fate decisions during early embryogenesis, and perhaps the best model organism where this was elegantly worked out is the Xenopus system. 49 After fertilization, the process of cortical rotation moves a dorsalizing factor to the future dorsal side of the embryo to establish the formation ...
Canonical and Non-Canonical Wnt Signaling in Immune Cells
Experimental findings in recent years suggest that Wnt signaling plays important roles in lymphomyelopoiesis and immune responses. The canonical Wnt signaling proteins can exert their roles in T cell differentiation and effector function in various inflammatory diseases including cancer, as well as in autoimmunity and viral infections.
Canonical and noncanonical Wnt signaling: Multilayered …
2024年1月1日 · Wnt signaling can be categorized into two pathways, the β-catenin-dependent pathway (canonical) and the β-catenin-independent pathway (noncanonical). 15,16 The canonical pathway is important for inducing cell proliferation, differentiation, and maturation. 16 It is also vital in producing proper body-axis specifications. 17 The pathway is activa...
Canonical and Non-Canonical Wnt Signaling in Immune Cells
We introduce recent key findings and future perspectives on Wnt ligands and their signaling pathways in immune cells as well as the immunological roles and functions of Wnt antagonists.
Canonical and noncanonical Wnt signaling: Multilayered …
2023年3月24日 · Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the ca …
Cell Biology of Canonical Wnt Signaling - PubMed
2021年10月6日 · We review recent investigations that uncover new cell physiological effects through the regulation of Wnt receptor endocytosis, Wnt-induced stabilization of proteins (Wnt-STOP), macropinocytosis, increase in lysosomal activity, and metabolic changes.