Calmodulin - Wikipedia
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. [1] It is an intracellular target of the secondary messenger Ca 2+, and the binding of Ca 2+ is required for the activation of calmodulin.
Calmodulin - Definition, Function and Structure - Biology Dictionary
2017年7月4日 · Calmodulin, or calcium-modulated protein, is a calcium-binding protein found in the cytoplasm of all eukaryotic cells. It interacts with many other proteins in the cell, and acts as a regulator or an effector molecule in a wide variety of cellular functions.
Molecule of the Month: Calmodulin - RCSB: PDB-101
Calmodulin changes shape when it binds to calcium and can activate over 300 essential proteins. Each of its four high-affinity calcium binding sites, called EF-hands, contains a characteristic loop flanked by two alpha helices.
Calmodulin - an overview | ScienceDirect Topics
Calmodulin, the ubiquitous and multifunctional Ca 2+ binding protein, mediates many of the regulatory effects of Ca 2+, including the contractile state of smooth muscle. Calmodulin was discovered as an activator of cyclic nucleotide phosphodiesterase (PDE) (Cheung, 1970; Kakiuchi et …
Calmodulin 1 - Wikipedia
Calmodulin 1 is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding EF hand motifs.
Calmodulin | Clinical Center - National Institutes of Health
Calmodulin is a ubiquitous, highly conserved protein that plays a critical role in numerous essential cellular functions, including Ca 2+ transport, cell motility, cytoskeletal assembly, protein phosphorylation/dephosphorylation, cell proliferation and cell cycle progression.
Molecular Dynamics Study of the Changes in Conformation of Calmodulin ...
2019年7月23日 · Calmodulin is a calcium binding protein with two lobes, N-lobe and C-lobe, which evolved from duplication and fusion of a single precursor lobe of a pair of EF-hand.
Calmodulin: a prototypical calcium sensor - PubMed
Calmodulin is the best studied and prototypical example of the E-F-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First, at the cellular level, by directing its subcellular distribution.
Calmodulin - an overview | ScienceDirect Topics
Calmodulin is the major regulator of Ca 2+-dependent signalling pathways in eukaryotic cells, mediating many physiological processes. For example, calmodulin binding to the v-SNARE VAMP2 is required for regulated exocytosis. The role …
Calmodulin: The switch button of calcium signaling - PubMed
2021年8月23日 · Calmodulin (CaM), a calcium sensor, decodes the critical calcium-dependent signals and converts them into the driving force to control various important cellular functions, such as ion transport.