CDC42 - Wikipedia
Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle.
CDC42 Gene - GeneCards | CDC42 Protein | CDC42 Antibody
2024年10月1日 · CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Nocarh Syndrome. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and GPCR Pathway.
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes …
Cdc42 interacting protein-4 (CIP4) is involved in regulating cytoskeleton, membrane trafficking via interacting with the GTP-bound Cdc42 and positively related to insulin signalling and GLUT4 translocation through interacting with TC10.
Cdc42 mobility and membrane flows regulate fission yeast cell
2024年9月27日 · A reaction-diffusion particle model comprising Cdc42 positive feedback activation, hydrolysis by GTPase-activating proteins (GAPs), and flow-induced displacement by exo/endocytosis shows that...
Cdc42 regulates cell polarization and contractile actomyosin rings ...
2020年7月16日 · Cdc42 regulates the formation of the actin cytoskeleton and microtubule assembly through several effector proteins, such as the IQ motif-containing GTPase-activating protein (IQGAP),...
Signaling Role of Cdc42 in Regulating Mammalian Physiology
Cdc42 is a member of the Rho GTPase family of intracellular molecular switches regulating multiple signaling pathways involved in actomyosin organization and cell proliferation. Knowledge of its signaling function in mammalian cells came mostly from ...
Cdc42: An important regulator of neuronal morphology
2012年3月1日 · Similar to other small GTPases, activation of Cdc42 can be directly regulated by three classes of proteins: (i) guanine nucleotide exchange factors (GEFs), which catalyze the exchange of GDP with GTP and shift Cdc42 into the activated state, (ii) GTPase activating proteins (GAPs), which accelerate GTP-hydrolysis, rendering Cdc42 inactive, and ...
Role of a small GTPase Cdc42 in aging and age-related diseases
2023年1月4日 · Cell division control protein 42 homolog, also known as Cdc42, is a small GTPase of the Rho family (Colicelli 2004; Mosaddeghzadeh and Ahmadian 2021; Wennerberg et al. 2005) involved in a wide range of basic cellular functions. The priority in the discovery of Cdc42 belongs to a team of researchers led by John Pringle from the University of ...
Cdc42 subcellular relocation in response to VEGF/NRP1
2020年3月5日 · VEGF/NRP1-activated Cdc42 induces the formation of filopodia in CRC cells. Cdc42 was found to activate LIMK2 and subsequently phosphorylate cofilin, which thereby promoted F-actin formation for...
Activation of Endogenous Cdc42 Visualized in Living Cells | Science …
2004年9月10日 · The ability to detect endogenous protein with the high sensitivity provided by the dye was important in studying Cdc42. High sensitivity enabled detection of protein activation at native concentrations, unlike previous fluorescence resonance energy transfer (FRET) biosensors that required overexpression of Cdc42 ( 11 ), and showed more uniform ...