Basophils in inflammation - PubMed
2016年5月5日 · Basophil numbers increase in response to IL-3 or TSLP and migrate into tissues to promote type 2 immune responses. Here we review recent advances regarding the pro- and anti-inflammatory functions of basophils in murine models and human allergic inflammation of the skin, lung and intestine.
Basophils in inflammation - ScienceDirect
2016年5月5日 · Basophil numbers increase in response to IL-3 or TSLP and migrate into tissues to promote type 2 immune responses. Here we review recent advances regarding the pro- and anti-inflammatory functions of basophils in murine models and human allergic inflammation of the skin, lung and intestine.
Basophils and allergic inflammation - PMC - PubMed Central …
Animal model systems have provided some insights into potential roles for basophils in contributing to the development or propagation of allergic airway inflammation. For example, in a recent study employing a murine model of HDM-induced airway inflammation, basophils were found to play a direct role in promoting optimal T H 2 cytokine ...
Basophils in autoimmune and inflammatory diseases - Nature
2014年11月25日 · We are beginning to understand the importance of basophils in the pathogenesis of autoimmune and inflammatory diseases and the molecular mechanisms implicated in these processes.
Role of Basophils in a Broad Spectrum of Disorders - PMC
Depletion of basophils in the inflammation phase resulted in the improvement of barrier dysfunction, indicating the proinflammatory role of basophils. By contrast, either basophil-specific macrophage colony-stimulating factor (M-CSF)-deficiency or IL-4 neutralization resulted in aggravated ear swelling and skin barrier dysfunction in the ...
Emerging roles of basophils in allergic inflammation - PubMed
Basophils play crucial roles in both IgE-dependent and -independent allergic inflammation, through their migration to the site of inflammation and secretion of various mediators, including cytokines, chemokines, and proteases. Basophils are known to produce large amounts of IL-4 in response to various stimuli.
Basophils and allergic inflammation - Journal of Allergy and …
2013年6月21日 · After encountering antigen, IL-3–elicited basophils release multiple effector molecules that can contribute to allergic inflammation. TSLP-elicited basophils are nonresponsive to IgE-antigen complexes but produce multiple effector molecules after stimulation with cytokines, such as IL-33 and IL-18.
Basophil differentiation, heterogeneity, and functional …
2024年6月28日 · Using Mcpt8 DTR mice and antibody-induced basophil depletion in the AD model, basophils were shown to play important roles in the development of skin inflammation in AD . Recently, basophils were identified as key mediators in T H 2 responses and the complex immune–neuron axis in AD.
The role of basophils in inflammatory reactions - PubMed
Basophils contain and release histamine, the eosinophil chemotactic factor of anaphylaxis (ECFA), a slow reacting substance of anaphylaxis (SRS-A), and a kallikrein. The release process is controlled by hormone-basophil receptor interactions that determine the cyclic AMP level; plasma and tissue adenosine levels appear prominent in this control.
Emerging roles of basophils in allergic inflammation
2017年7月1日 · Basophils play crucial roles in both IgE-dependent and -independent allergic inflammation, through their migration to the site of inflammation and secretion of various mediators, including cytokines, chemokines, and proteases. Basophils are known to produce large amounts of IL-4 in response to various stimuli.