B-cell receptor - Wikipedia
The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor includes both CD79 and the immunoglobulin . The plasma membrane of a B cell is indicated by the green phospholipids .
Role of B-cell receptors for B-cell development and antigen …
Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells.
B-cell receptor: from resting state to activate - PMC
B-cell activation is triggered by the binding of antigen to the B-cell receptor (BCR). The early molecular events triggered by BCR binding of ligand have been well-characterized both biochemically and using optical microscopy techniques to visualize B-cell activation as it happens.
Structural principles of B cell antigen receptor assembly
2022年10月13日 · Cryo-electron microscopy structures of the mouse class M immunoglobulin B cell receptor complex provide insight into B cell receptor subunit assembly, domain architecture and signalling...
B Cells and Antibodies - Molecular Biology of the Cell - NCBI …
Each B cell has approximately 10 5 such receptors in its plasma membrane. As we discuss later, each of these receptors is stably associated with a complex of transmembrane proteins that activate intracellular signaling pathways when antigen binds to the receptor.
Towards a unifying model for B-cell receptor triggering
2024年9月10日 · The four main models proposed to explain BCR triggering of the basis of experimental data: cross-linking (clustering), dissociation–activation, conformation-induced oligomerization, and kinetic...
Study Reveals Detailed Structure of B-Cell Receptor
2022年10月25日 · Cryo-EM revealed the structure of the B-cell receptor in unprecedented detail. Images: Wu lab. The receptor is known as IgM because its main components are immunoglobulin M antibodies. (The B-cell receptor’s four siblings are IgA, IgD, IgE, and IgG.)
Unveiling the B cell receptor structure | Science - AAAS
2022年8月18日 · B cells took center stage in the COVID-19 pandemic as the world waited anxiously for a vaccine. Nearly all vaccines in use today depend on activating B cells by binding to the surface-expressed B cell receptors (BCRs) that …
How B cells capture, process and present antigens: a crucial role …
2013年6月25日 · B cells form immunological synapses upon engagement of their B cell receptor (BCR) with antigen that is exposed at the surface of specialized presenting cells. Synapse formation promotes the...
B-Cell Receptor - an overview | ScienceDirect Topics
The B cell receptor (BCR) covers the surface of mature B cells, and initiates cellular responses that lead to B cell activation and antibody production. Each B cell expresses a unique B cell receptor with specificity for a unique antigen.