Amyloid beta: structure, biology and structure-based …
2017年7月17日 · In this paper, we review the structures, biological functions, and neurotoxicity role of Aβ. We also discuss the potential receptors that interact with Aβ and mediate Aβ intake, …
Amyloid beta: structure, biology and structure-based …
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain …
Amyloid beta - Wikipedia
Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's …
6SZF: Solution structure of the amyloid beta-peptide (1-42)
2019年10月2日 · Aβ (1-42) structure was solved by us, giving evidence that the evolution of Aβ (1-42) peptide from helical to the β-sheet may follow unexpected routes. Molecular dynamics …
Solution structure of the Alzheimer's disease amyloid beta
2002年9月6日 · The major components of neuritic plaques found in Alzheimer disease (AD) are peptides known as amyloid beta-peptides (Abeta), which derive from the proteolitic cleavage …
Aggregation and structure of amyloid β-protein - ScienceDirect
2021年12月1日 · Mechanism of amyloid β-protein (Aβ) aggregation. The pathway of Aβ aggregation starts with random structured monomers and ends with amyloid fibrils. …
Structure of amyloid-β (20-34) with Alzheimer’s-associated ...
2019年7月26日 · Isomerized products of aspartic acid residues perturb protein structure by rerouting the peptide backbone through the side chain β-carbonyl. This age-dependent …
Biology of amyloid: structure, function, and regulation
2010年10月13日 · Amyloids are highly ordered cross-β sheet protein aggregates associated with many diseases including Alzheimer's disease, but also with biological functions such as …
Biology of Amyloid: Structure, Function, and Regulation - Cell Press
The cross-β sheet entity comprising an indefinitely repeating intermolecular β sheet motif is unique among protein folds. It grows by recruitment of the corresponding amyloid protein, …
Fibril structure of amyloid-β(1–42) by cryo–electron microscopy
2017年9月7日 · Fibrillar aggregates of the amyloid-β protein (Aβ) are the main component of the senile plaques found in brains of Alzheimer’s disease patients. We present the structure of an …