Akt/PKB signaling pathway - Wikipedia
The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (protein kinase B).
The Akt pathway in oncology therapy and beyond (Review) - PMC
Akt is the core of a complex signaling pathway that is one of the most intensively investigated cell signaling networks due to its crucial involvement in cell metabolism, growth, proliferation, motility, survival and apoptosis.
Akt: a key transducer in cancer - PMC - PubMed Central (PMC)
Akt signaling orchestrates cellular functions and tumorigenesis. Although more than 200 Akt substrates have been identified over the past decades, only a few have been validated to be critical in Akt-mediated cancer development.
PI3K Akt Pathway - Cell Signaling Technology
Akt regulates cell growth through its effects on the TSC1/TSC2 complex and mTORC signaling. Akt contributes to cell proliferation via phosphorylation of the CDK inhibitors p21 and p27. Akt is a major mediator of cell survival through direct inhibition of pro-apoptotic proteins like Bad or inhibition of pro-apoptotic signals generated by ...
PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for …
2022年3月24日 · Herein, we discuss the molecular and cellular regulation between cytoskeletal proteins and the PI3K/AKT signaling pathway, and how these two orchestrate a regulatory process that aids cancer progression.
Targeting PI3K/Akt signal transduction for cancer therapy
2021年12月16日 · In this review, we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes, review the current statuses of different PI3K/Akt inhibitors, and introduce combination therapies...
The PI3K-AKT network at the interface of oncogenic signalling and ...
Here, we review the physiological functions of the PI3K-AKT network in controlling metabolic networks and the potential consequences from oncogenic PI3K-AKT signaling leading to dysregulation of these key metabolic control points in cancer cells and tumors.
AKT/PKB Signaling: Navigating the Network - Cell Press
In the context of a network-based view of AKT signaling, we highlight the three best-established downstream targets of AKT, which are also key signaling nodes that integrate AKT signaling with additional cellular regulatory circuits.
Akt Signaling - an overview | ScienceDirect Topics
Akt signaling is a central pathway regulating metabolism, proliferation, cell survival and angiogenesis in response to various extracellular cues. The aberrant Akt network accounts for various pathogenesis such as developmental and overgrowth syndromes, cancer, cardiovascular disease, insulin resistance and type-2 diabetes, inflammatory and ...
AKT/PKB Signaling: Navigating the Network - PubMed
2017年4月20日 · Our comprehension of AKT regulation and functions is particularly important given the consequences of AKT dysfunction in diverse pathological settings, including developmental and overgrowth syndromes, cancer, cardiovascular disease, insulin resistance and type 2 diabetes, inflammatory and autoimmune disorders, and neurological disorders.