Adalimumab - StatPearls - NCBI Bookshelf
2023年11月12日 · Adalimumab is a fully human, recombinant monoclonal antibody (mAb) with high affinity, acting as an inhibitor of tumor necrosis factor-alpha (TNF-α). Adalimumab is used to treat various autoimmune conditions such as rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, Crohn disease, and ulcerative colitis.
Adalimumab: Uses, Interactions, Mechanism of Action - DrugBank …
Adalimumab is a monoclonal anti-tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis.
Adalimumab - Wikipedia
Adalimumab, sold under the brand name Humira and others, is a disease-modifying antirheumatic drug and monoclonal antibody used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis.
Tumor Necrosis Factor Inhibitors - StatPearls - NCBI Bookshelf
2023年7月3日 · Tumor necrosis factor (TNF)-alpha inhibitors, including etanercept (E), infliximab (I), adalimumab (A), certolizumab pegol (C), and golimumab (G), are biologic agents which are FDA-approved to treat ankylosing spondylitis (E, I, A, C, and G), Crohn disease (I, A and C), hidradenitis suppurativa (A), juvenile idiopathic arthritis (A), plaque ...
Adalimumab - PubMed
Adalimumab is a fully human, recombinant monoclonal antibody with high affinity and was the third tumor necrosis factor-alpha (TNF-α) inhibitor. Adalimumab is used to treat various autoimmune conditions such as rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, Crohn disea …
Adalimumab: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月17日 · Adalimumab decreases signs and symptoms of psoriatic arthritis, rheumatoid arthritis, and ankylosing spondylitis. It inhibits progression of structural damage of rheumatoid and psoriatic arthritis.
Humira Mechanism Of Action - My Endo Consult
Humira belongs to a group of medicines known as TNF-alpha inhibitors. Its active ingredient, Adalimumab, is a specially designed monoclonal antibody that specifically targets and binds to tumor necrosis factor-alpha (TNF-α).
Comparison of the Inhibition Mechanisms of Adalimumab and …
2013年9月9日 · The structural observation and the mutagenesis analysis provided direct evidence for identifying the Adalimumab epitope on TNFα and revealed the mechanism of Adalimumab inhibition of TNFα by occupying the TNFα receptor-binding site.
Adalimumab - Nature Reviews Drug Discovery
2003年9月1日 · Adalimumab (Humira; Abbott), an antibody that binds specifically to the inflammatory cytokine TNF-α, was approved by the US FDA for the treatment of moderate to severe rheumatoid arthritis in...
Adalimumab - PubChem
Adalimumab is a monoclonal antibody to human tumor necrosis factor (TNF) alpha which has potent antiinflammatory activity and is used in the therapy of severe rheumatoid arthritis and inflammatory bowel disease. Adalimumab has been linked to rare instances of idiosyncratic acute liver injury and is a potential cause of reactivation of hepatitis B.
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