PTEN alleviates maladaptive repair of renal tubular epithelial cells …
To investigate the role of PTEN in I/R-induced renal maladaptive repair, we constructed mouse models where renal proximal tubular cells (RPTCs) specifically overexpressed PTEN and also cultured HK-2 cell models.
Renal tubular epithelial cells: the neglected mediator of ... - Nature
2018年11月13日 · Cell Death & Disease - Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury
Renal tubular epithelial cells response to injury in acute kidney ...
2024年9月1日 · WT1 + PECs can develop into WT1 + proximal renal tubular epithelial cells through a transient phase of scattered tubular cells, which are essential for proximal tubular regeneration of the kidney after severe AKI.
Epithelial proliferation and cell cycle dysregulation in kidney …
Various cellular insults and injury to renal epithelial cells stimulate repair mechanisms to adapt and restore the organ homeostasis. Renal tubular epithelial cells are endowed with regenerative capacity, which allows for a restoration of nephron function after acute kidney injury.
Cellular senescence of renal tubular epithelial cells in acute …
2024年2月5日 · The senescence of renal tubular epithelial cells (RTEC) constitutes a critical cellular event in the progression of acute kidney injury (AKI).
Roles of DNA damage in renal tubular epithelial cells injury
2023年4月6日 · In recent years, several developments have been made in the field of DNA damage. Herein, we review the roles and developments of DNA damage and DNA damage response in renal tubular epithelial cell injury in acute kidney injury and chronic kidney disease.
Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?
2018年1月24日 · In summary, the Wnt/β-catenin signaling pathway is critical for proper nephron development and is re-activated in the injured renal tubular epithelium and, specifically, the proliferating tubular progenitors that repopulate the tubule after injury.
Chromatin accessibility dynamics dictate renal tubular epithelial cell ...
2022年11月28日 · Nature Communications - Renal tubular epithelial cells (TECs) can initiate an adaptive or maladaptive response after injuries of different severity. Here, the authors elucidate a...
Renal tubular epithelial cells: the neglected mediator of ...
2018年11月13日 · It is the consequence of maladaptive repair by tubular cells and has a strong correlation with renal fibrosis. In uninjured kidneys, most tubular cells remain in the quiescent G0 phase. Upon insult, TECs enter the cell cycle to regenerate …
Renal microenvironments and macrophage phenotypes determine progression ...
2011年11月1日 · Triggers of renal cell damage activate renal cells, which results in subsequent activation of innate and potentially adaptive immunity. This includes the recruitment of monocytes that will differentiate into different macrophage phenotypes depending on the …