Medulloblastomas Initiated by Homologous Recombination …
2024年8月19日 · Germline mutations of homologous-recombination (HR) genes are among the top contributors to medulloblastomas. A significant portion of human medulloblastomas exhibit …
Medulloblastomas Initiated by Homologous Recombination …
2024年8月18日 · As mentioned earlier, human MBs are currently classified into four molecular groups. 4–6 Groups 1, 2, and 3 are characterized by the activation of the WNT, SHH, and Myc …
Molecular Stratification of Medulloblastoma: Clinical Outcomes …
The key molecular drivers of SHH pathway genes in MBs include mutations and other genetic alterations in known pathway genes in 116 (87%) of 133 SHH tumors . In addition, structural …
Molecular stratifications, biomarker candidates and new …
Adults with Group 4 MBs have a significantly worse prognosis compared to the SHH- or WNT-activated subtypes . Group 3 and Group 4 MBs are genetically heterogeneous, not driven by …
Molecular markers and potential therapeutic targets in non …
2019年3月15日 · We summarize the most frequent genetic aberrations of group 3 MBs in Table 1 and group 4 MBs in Table 2. Tumor proteome analysis defines novel potentially targetable …
Pathology, diagnostics, and classification of medulloblastoma
SHH MB are characterized by activation of SHH pathway transcriptional programs and recurrent mutations in SHH pathway genes including PTCH1, SMO, and SUFU (34, 68). Amplifications …
Molecular stratifications, biomarker candidates and new …
2020年1月22日 · Currently, two clinical trials are investigating blockade of classical inhibitory checkpoint pathways in MBs (Table 2). The goal of the NCT02359565 phase I trial is to assess …
Drivers Underlying Metastasis and Relapse in Medulloblastoma …
2024年4月30日 · Leptomeningeal spread in MB has been associated with several molecular pathways. The chemokine receptor CXCR4 and its ligand CXCL12 (aka. SDF-1) promote cell …
Convergence of BMI1 and CHD7 on ERK Signaling in …
2017年12月12日 · We show that BMI1-mediated repression of the ERK1/2 pathway leads to increased proliferation and tumor burden in primary human MB cells and in a xenograft model, …
BAI1 Suppresses Medulloblastoma Formation by Protecting
We show the ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (BAI1), is epigenetically silenced in medulloblastomas (MBs) through a methyl-CpG binding protein …