Alveolar fibroblast lineage orchestrates lung inflammation and
2024年7月10日 · Alveolar fibroblast ablation significantly increased weight loss and mortality with increased IgM in bronchoalveolar lavage fluid (BAL) (Fig. 1n) and neutrophil infiltration (Fig. 1o),...
Idiopathic pulmonary fibrosis (IPF): Diagnostic routes using novel ...
2024年8月1日 · Fibroblasts are the primary effector cells causing lung fibrogenesis in IPF patients [7]. Upon injury, fibroblast activation leads to their proliferation, migration, and remodeling of the lung extracellular matrix, resulting in progressive functional deterioration and, …
Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality. With an increase in life expectancy, the economic burden of IPF …
Single-cell RNA sequencing reveals special basal cells and fibroblasts …
2024年7月9日 · In this paper, we established a single-cell transcriptome atlas of IPF lung and found an elevation in the number of stromal cells, including fibroblasts and endothelial, mural, and ECs in the...
Role of interleukins in the pathogenesis of pulmonary fibrosis
2021年3月15日 · Pulmonary fibrosis (PF) is a chronic, progressive fibrotic lung pathological change that can be observed in idiopathic pulmonary fibrosis (IPF), systemic sclerosis,...
TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF ...
2020年2月18日 · Fibrotic diseases, such as IPF, are characterized by uncontrolled activation of fibroblasts. Since the microenvironment is known to affect cell behavior, activated fibroblasts can in turn activate healthy neighboring cells. Thus, we investigated IPF paracrine signaling in human lung fibroblasts (HLFs) derived from patients with IPF. Methods.
Epithelial-fibroblast interactions in IPF: Lessons from in vitro co ...
2023年11月1日 · IPF-ABCs form bronchoshperes and adding IPF lung fibroblasts enhanced bronchosphere formation. Increased CTGF leads to fibrosis. Dedifferentiated human IPF-ABCs have profibrotic traits both in vitro and in vivo .
Prognostic model of fibroblasts in idiopathic pulmonary fibrosis …
2024年7月30日 · In this study, we used scRNA-seq technology, which provides an opportunity to explore fibroblasts in IPF, to construct a fibroblast-related prognostic model for IPF. By clustering and annotating scRNA-seq data from the Gene Expression Omnibus (GEO) database, we obtained fibroblast subtypes.
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis
2020年11月25日 · The treatment of senescence-related molecules and pathways is continually emerging, and using senolytics eliminating senescent fibroblasts is also actively tried as a new therapy for IPF. In this review, we discuss the roles of aging and cellular senescence in IPF.
The Idiopathic Pulmonary Fibrosis Cell Atlas
2020年11月30日 · Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease that is characterized by replacement of the normal lung anatomy with active remodeling and deposition of extracellular matrix (ECM) accompanied by a shift in lung cellular communities. The most common outcome of this debilitating disease is respiratory failure and subsequent death.