Demethylase - Wikipedia
Demethylases are enzymes that remove methyl (CH 3) groups from nucleic acids, proteins (particularly histones), and other molecules. Demethylases are important epigenetic proteins, as they are responsible for transcriptional regulation of the genome by controlling the methylation of DNA and histones, and by extension, the chromatin state at ...
Molecular mechanisms and potential functions of histone ...
2012年4月4日 · Histone demethylase activity is regulated by expression levels, by targeting to specific sites in the genome and by post-translational modifications. Histone demethylases bind to many target...
LSD1: more than demethylation of histone lysine residues - Nature
2020年12月14日 · LSD1 was the first histone demethylase identified, and its presence on chromatin is crucial for the control of its plasticity through the regulation of histone methylation.
Histone demethylases in the regulation of immunity and ...
2023年6月23日 · Histone demethylases (KDMs) regulate gene expression and play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins.
Histone demethylases in chromatin biology and beyond - PMC
Histone demethylases have a clear function in resetting chromatin states in the germline and other reprogramming paradigms, but studies in fission yeast suggest that histone demethylation can also function to fine‐tune how chromatin states …
The emerging roles of histone demethylases in cancers - Springer
2024年1月16日 · Histone methylation and demethylation are chemically catalyzed by histone methyltransferase and demethylase, which achieve the balance of changes in DNA topology and lead to diverse biological functions.
Histone demethylase KDM2A: Biological functions and clinical ...
Histone lysine demethylation modification is a critical epigenetic modification. Lysine demethylase 2A (KDM2A), a Jumonji C domain-containing demethylase, demethylates the dimethylated H3 lysine 36 (H3K36) residue and exerts little or no activity on monomethylated and trimethylated H3K36 residues.