Fucoxanthin: A Promising Medicinal and Nutritional Ingredient
Metabolism and Bioavailability of Fucoxanthin. The absorption and metabolism of fucoxanthin are closely related to its bioavailability. It is essential to know the metabolic process and the method to improve the bioavailability of fucoxanthin (Figure 2).
Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds …
Fucoxanthinol, a metabolite of fucoxanthin, inhibited the cell migration and invasion of osteosarcoma cells, and reduced MMP-1 expression and AP-1 signaling . In addition, fucoxanthinol significantly suppressed sphere-forming activity, migration, and invasion of human colorectal cancer cell lines HT-29 and HCT116 in a dose-dependent manner [ 99 ...
Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer …
2015年7月31日 — When ingested, it is metabolized mainly to fucoxanthinol by digestive enzymes of the gastrointestinal tract. These compounds have been shown to have many beneficial health effects, including anti-mutagenic, anti-diabetic, anti-obesity, anti …
Fucoxanthin - SpringerLink
Metabolism of fucoxanthin occurred in two steps, step one included the hydrolysis of fucoxanthin to its active metabolites fucoxanthinol and amarouciaxanthin A in the presence of pancreatic juice, which contains lipase, phospholipase, and cholesterol esterase in the gastrointestinal tract (Sugawara et al. 2002).
Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer ... - MDPI
2015年7月31日 — Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. When ingested, it is metabolized mainly to fucoxanthinol by digestive enzymes of the gastrointestinal tract. These compounds have been shown to have many beneficial health effects, including anti-mutagenic, anti-diabetic, anti-obesity, anti-inflammatory and anti ...
Fucoxanthin from Algae to Human, an Extraordinary Bioresource: …
All of the current most performant species for high fucoxanthin production are marine microalgae whose growth depends on the salinity of the medium which acts as osmotic control of metabolites. The study of Ishika et al. showed that P. tricornutum grew well and produced more fucoxanthin at optimal salinity of 45‰, while halophile microalgae ...
Antioxidant and Neuroprotective Effects of Fucoxanthin and Its ...
2024年6月14日 — In this study, we compared the antioxidant activity of fucoxanthin and its metabolite fucoxanthinol in terms of free radical scavenging activity and induction of endogenous antioxidant response at the neuronal level and the neuroprotective effects against the neurotoxicity mediated by AβO and 6-OHDA in neuronal SH-SY5Y cells.
Fucoxanthin metabolites exert anti-fibrogenic and antioxidant effects ...
2021年12月1日 — FCN and ACXA significantly reduced cellular ROS accumulation triggered by TGFβ1, concomitantly decreasing antioxidant gene expression. It has known that fucoxanthin metabolites have a unique chemical structure containing allenic bond, which can confer antioxidant properties by scavenging singlet molecular oxygen and free radicals [22]. Thus ...
Health benefits of fucoxanthin in the prevention of chronic diseases
2020年11月1日 — Furthermore, fucoxanthin and its metabolite, fucoxanthinol, showed an inhibitory effect on adipocyte differentiation in 3T3-L1 adipocyte, as evidenced by reduced intracellular lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity, which was attributed to the downregulation of PPARγ expression [79]. Fucoxanthinol exhibited ...
Fucoxanthin, a Functional Food Ingredient: Challenges in ...
2023年8月29日 — Fucoxanthin and its metabolites, fucoxanthinol and halocynthiaxanthin, were found to inhibit lipid peroxidation in vitro in a concentration-dependent manner. Fucoxanthin inhibited lipid peroxidation with an IC 50 value of 3 µM, while fucoxanthinol and halocynthiaxanthin had IC 50 values of 5 and 7 µM, respectively.
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