Nature重磅：Senolytics之父带你一文读懂衰老细胞清除机制与治疗 …
清除衰老细胞的疗法——Senolytic疗法. 既然是衰老细胞引起了衰老，那么从理论上来讲清除衰老细胞就可以延缓衰老，科学家们根据这个思路开发出了Senolytic疗法，“seno”是衰老的意思，“lytic”是摧毁意思，直译是摧毁衰老，准确地来说就是摧毁衰老细胞。
Cellular senescence and senolytics: the path to the clinic
2022年8月11日 · These genetic models have been useful in pinpointing those cells expressing particular senescence-linked markers (for example, p16 INK4a or p21 CIP1/WAF1) and as complementary tools in...
Senolytic therapy alleviates physiological human brain aging
2023年11月13日 · In the brains of SARS-CoV-2-infected K18-hACE2 mice we found that senolytic treatment alleviates p16 and the levels of proinflammatory cytokines that may be due, in part, to removal of virus ...
Chronic social stress induces p16-mediated senescent cell
4 天之前 · p16 Ink4a-positive SNCs can drive aging-related diseases and shorten ... P. et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in ...
First evidence that senolytics are effective at decreasing senescent ...
2019年9月19日 · The findings suggest that senolytics given intermittently in a ‘hit-and-run’ fashion, despite the elimination half-lives of D and Q being <11 h, is effective at reducing senescent cell burden and could lessen side effects, which can …
A pipeline for senolytics - PMC - National Center for …
2024年5月5日 · Lee et al. developed an approach for high-throughput screening of senolytic compounds. In Lee et al. , senescence is induced in mice that express a highly sensitive p16 Ink4a reporter, termed INKBRITE, followed by fluorescence-activated cell sorting (FACS) for GFP + (p16 Ink4a+) and GFP – (p16 Ink4a–) cells.
Senolytic targets and new strategies for clearing senescent cells
2021年4月1日 · Multiple stressors and damaging stimuli activate pathways that converge on the activation of cell cycle inhibitors. Senescent cells are characterized by enlarged and irregular shape, increased levels of p16/p21, SASP and ROS, high β-galactosidase activity and decreased expression of Lamin B1.
Identifying specific functional roles for senescence across cell types
2024年10月4日 · This study illuminates the functional diversity of p16 Ink4a+ cells and offers insights for developing cell-type-specific senolytic therapies in the future.
A senolytic immunotoxin eliminates p16 - PubMed
We herein describe a novel approach to eliminate p16-expressing cells from mice at any given point in time, generating a new type of knock-in model, p16hCD2 mice and a toxin-conjugated anti-human CD2 antibody (hCD2-SAP) as an inducer. p16hCD2 mice possess an intact Cdkn2a locus that includes a p16 coding region and human CD2 (hCD2) expression unit.
Multiparametric senescent cell phenotyping reveals targets of senolytic …
2023年7月31日 · These p16 + Ki67-BCL-2+ cells are highly enriched for senescence-associated secretory phenotype and DNA damage markers, are strongly associated with age, and their percentages are increased in...