Gabazine - Wikipedia
Gabazine (SR-95531) is a drug that acts as an antagonist at GABA A receptors. It is used in scientific research and has no role in medicine, as it would be expected to produce convulsions if used in humans.
Gabazine - an overview | ScienceDirect Topics
Gabazine (SR 95531) is the most potent competitive GABAA receptor antagonist of the pyridazinyl-GABA derivatives (for a review see Wermuth and Biziere, 1986).
Advantages of an antagonist: bicuculline and other GABA …
Gabazine, as SR 95531, was introduced as a specific, potent and competitive GABA A antagonist in 1986 as a result of the study of arylaminopyridazine derivatives of GABA (Heaulme et al., 1986).
GABA Inhibitors - StatPearls - NCBI Bookshelf
2023年7月30日 — Gamma-aminobutyric acid (GABA) inhibitors, or GABA antagonists, are drugs that inhibit the action of GABA, the primary inhibitory neurotransmitter of the central nervous system. They predominantly work at the GABA receptor.
Gabazine - an overview | ScienceDirect Topics
Gabazine (Fig. 3, also known as SR 95531) is a relatively specific, potent and competitive antagonist of GABA A receptors (Heaulme et al., 1986). Structural analogs of gabazine have been developed as more potent agents (Iqbal et al., 2011).
Gabazine - an overview | ScienceDirect Topics
47.4 GABA is the Main Neurotransmitter Released from Immature MF Terminals. Immediately after birth, GABA appears to be the only neurotransmitter released from MF terminals.
Bicuculline and gabazine are allosteric inhibitors of channel opening ...
1997年1月15日 — Bicuculline or gabazine (two competitive antagonists of GABA binding) reduced the currents elicited by alphaxalone and pentobarbital from wild-type GABAA receptors; however, gabazine produced only a partial block of response pentobarbital or alphaxalone, and bicuculline only partially blocked responses to pentobarbital.
GABA tone regulation and its cognitive functions in the brain
2023年7月26日 — γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at GABAergic synapses, mediating fast-acting phasic inhibition.
Structural determinants and regulation of spontaneous activity …
2021年9月15日 — GABA A receptors are vital for controlling neuronal excitability and can display significant levels of constitutive activity that contributes to tonic inhibition. However, the mechanisms...
Photo-antagonism of the GABA A receptor - Nature
2014年7月29日 — Nature Communications - The GABAA receptor has an important role in brain function. Here Mortenson et al. design and synthesize photoactivatable compounds based on the GABAAantagonist...