DNA damage response signaling pathways and targets for …
2020年5月1日 · DNA double-strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular DNA damage responses (DDRs), including those helping cells recover...
Ionizing-radiation induced DNA double-strand breaks: A direct …
2013年9月1日 · Ionizing radiation (IR) produce a wide variety of DNA lesions among them double-strand breaks (DSBs), considered to be the major actor responsible for cell death. If unrepaired or improperly repaired, DSBs contribute to chromosomal aberrations, which may lead to human disorders including cancer [1].
Advanced Science | 中国科学院陈策实团队发现RNF126调控DNA损 …
2022年12月30日 · 在大多数癌症中，一种或多种ddr途径或能力的丧失会增大其它途径的被依赖性，为通过靶向ddr提高ir敏感性提供了可能。 IR主要通过诱导DNA损伤，特别是DNA双链断裂（DSB）导致细胞死亡。
DNA损伤应答 - 百度百科
DNA损伤应答是细胞内一种非常保守的抵御外界及内在因素诱导的DNA 损伤的机制， 是由多条信号传导通路构成的网络来监测和传递损伤信号， 并形成一个适当的应答机制， 包括 细胞周期检验点 及 基因表达 的调控等效应。 DNA损伤应答机制重要而复杂，生物主要通过两种手段，即 DNA损伤修复 和细胞凋亡，来保护其正常的生理功能和稳定的遗传性状。 在生物的生命周期中，DNA的复制、细胞的分裂或基因组受到损伤 (如内源性的氧化代谢产物和外源性的药物等)， …
High-LET-Radiation-Induced Persistent DNA Damage Response
2023年6月7日 · The IR-induced DDR initiates cell cycle arrest to repair damaged DNA. When DNA damage is beyond the cellular repair capacity, the DDR for cell death is initiated. An alternative DDR-associated anti-proliferative pathway is the onset of cellular senescence with persistent cell cycle arrest, which is primarily a defense mechanism against oncogenesis.
The Cellular Response to Complex DNA Damage Induced by …
2023年3月3日 · The DNA damage response (DDR) is a sophisticated signalling network that is used in cells to detect and repair a range of different DNA lesions. In terms of IR, the major types of DNA lesions induced are SSBs, base damage (sites of base loss/AP sites, or oxidised DNA bases) and CDD, which includes simple and complex DSBs, as well as non-DSB ...
The Cellular Response to Complex DNA Damage Induced by …
The DNA damage response (DDR) is a sophisticated signalling network that is used in cells to detect and repair a range of different DNA lesions. In terms of IR, the major types of DNA lesions induced are SSBs, base damage (sites of base loss/AP sites, or oxidised DNA bases) and CDD, which includes simple and complex DSBs, as well as non-DSB ...
Triple kill: DDR inhibitors, radiotherapy and immunotherapy leave ...
2022年10月21日 · Distorted DNA generated by irradiation causes replication stress, triggering the p53-mediated degradation process, or apoptosis, to prevent tumor expansion and then trigger the DNA damage response (DDR) [6]. DDR is a protective mechanism that recognizes DNA lesions and activates DNA repair mechanisms. RT kills cancer cells by generating DNA damage.
Olaparib and ionizing radiation trigger a cooperative DNA …
2019年5月17日 · One mainstay of cancer treatment is based on the generation of catastrophic DNA damage in tumor cells, particularly those that directly damage DNA, which include ionizing radiation (IR), among others. IR generates reactive oxygen species that attacks DNA mostly causing single-strand, and if not repaired, double-strand breaks.
Damage-induced lncRNAs control the DNA damage response through ... - Nature
2017年11月27日 · Small non-coding RNAs termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR activation. Here we show that active DDRNAs specifically localize to their damaged...