Cerivastatin - Wikipedia
Cerivastatin is a pure synthetic drug, produced to create a more potent inhibitor of HMG-CoA reductase. Cerivastatin was the most potent inhibitor with an inhibitory constant of 0.5 μg/L, which made it already effective at a low dose. It is taken up orally as tablets, where it …
Cerivastatin: Uses, Interactions, Mechanism of Action - DrugBank …
Cerivastatin, a competitive HMG-CoA reductase inhibitor effective in lowering LDL cholesterol and triglycerides, is used to treat primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb).
Withdrawal of cerivastatin from the world market - PMC
Cerivastatin was recently withdrawn from the market because of 52 deaths attributed to drug-related rhabdomyolysis that lead to kidney failure. The risk was found to be higher among patients who received the full dose (0.8 mg/day) and those who received gemfibrozil concomitantly.
cerivastatin (Baycol): Drug Side Effects and Dosing - MedicineNet
Cerivastatin is a drug that lowers cholesterol in the blood by blocking the enzyme in the liver that is responsible for producing cholesterol. It lowers total cholesterol as well as the LDL subfraction of cholesterol in the blood.
Cerivastatin Side Effects: Common, Severe, Long Term - Drugs.com
Cerivastatin was withdrawn from the U.S. market in 2001. Contact your doctor immediately if you experience unexplained muscle pain , tenderness, or weakness, especially if it is accompanied by a fever or flu-like symptoms or yellowing of your skin or eyes.
Statin Safety and Associated Adverse Events: A Scientific …
2018年12月10日 · Cerivastatin was originally approved with a maximum recommended dose of 0.3 mg/d, which was subsequently extended to 0.4 and 0.8 mg. Postmarketing surveillance found that these higher doses, especially 0.8 mg, were associated with a much greater risk of myopathy and rhabdomyolysis than other statins when given alone, but especially in ...
Cerivastatin for lowering lipids - PMC - National Center for ...
2020年1月25日 · Cerivastatin was the most potent statin until it was withdrawn from the market due to a number of fatalities due to rhabdomyolysis, however, the dose‐related magnitude of effect of cerivastatin on blood lipids is not known.
Which Statin Is the Best Choice for Which Patient? | AAFP
2002年3月15日 · Statins (also known as 3-hydroxy-3-methyl-glutaryl coenzyme A [HMG-CoA] reductase inhibitors) are generally recognized as the treatment of choice in patients with hypercholesterolemia because they...
Baycol: Side Effects, Dosage & Uses - Drugs.com
2023年8月23日 · Baycol is used to reduce the amounts of LDL (bad) cholesterol and total cholesterol in your blood. Baycol also reduces the amounts of triglycerides (another type of fat) and apolipoprotein B (a protein needed to make cholesterol) in your blood and increases the amount of HDL (good) cholesterol in your blood.
Cerivastatin for lowering lipids - PMC - National Center for ...
2017年1月7日 · Before it was withdrawn, cerivastatin was prescribed to prevent adverse cardiovascular events and to lower blood total cholesterol and LDL cholesterol. Cerivastatin is rapidly absorbed, reaching peak plasma concentration within two to three hours and has a short half‐life, two to three hours.