An overview of sphingolipid metabolism: from synthesis to …
De novo sphingolipid synthesis begins at the cytosolic leaflet of the ER where a set of four enzyme groups coordinately generate ceramides of different acyl chain lengths from non-sphingolipid precursors.
Sphingolipid - Wikipedia
De novo sphingolipid synthesis begins with formation of 3-keto-dihydrosphingosine by serine palmitoyltransferase. [9] The preferred substrates for this reaction are palmitoyl-CoA and serine .
Regulation of cellular and systemic sphingolipid homeostasis
2024年6月18日 — Together, substrate-mediated correction of abnormal 1-deoxy-sphingolipids synthesis by SPT could be a potential strategy for modulating numerous diseases in which sphingolipid metabolism is...
Sphingolipids and their metabolism in physiology and disease
2017年11月22日 — This universe of sphingolipids, the sphingolipidome, is highly complex, with distinct molecular species of each of the bioactive lipids and metabolic interconnections that interconvert one...
Kicking off sphingolipid biosynthesis: structures of the serine ...
2021年2月8日 — The biosynthesis of sphingolipids is initiated by SPT. SPT mediates the condensation of an amino acid (almost always serine) with an acyl-CoA (the acyl group of, usually, but not always, the...
An overview of sphingolipid metabolism: from synthesis to …
Sphingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol backbones which are synthesized in the ER from nonsphingolipid precursors.
Sphingolipid Metabolic Pathway: An Overview of Major Roles …
This review discusses the role of the sphingolipid metabolic pathway in diabetes, Alzheimer's disease, and hepatocellular carcinoma, with a special emphasis on the changes in gene expression pattern in these disease conditions.
Sphingolipids in mitochondria—from function to disease
2023年11月21日 — Sphingolipid synthesis/metabolism: A brief overview. De novo synthesis of sphingolipids starts in the endoplasmic reticulum (ER) where serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis, the condensation of an amino acid with acyl-CoA into 3-Ketodihydrophingosine (KDHSph) (Figure 1). The second ...
Sphingolipids in Metabolic Disease: The Good, the Bad, and the …
Together, a better understanding of sphingolipid synthesis and degradation and how they are regulated by metabolic alterations holds great promise for the development of tractable therapeutic targets and approaches.
An Overview of Sphingolipid Metabolism: From Synthesis to …
Sphingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol backbones which are synthesized in the ER from nonsphingolipid precursors. Modification of this basic structure is what gives rise to the vast family of...