Pyrimidine: a review on anticancer activity with key emphasis on …
2021年6月19日 — Thiazolo[3,2-a] pyrido[4,3-d]pyrimidine containing derivatives were evaluated against the 60 different human tumor cell lines with 122(a–m) being the most potent. The different activity between the compounds was due to variation of substitutions in the phenyl group of the molecule and the presence of sulfur and nitrogen atom subsequently ...
Novel Pyrimidine Derivatives as Antioxidant and Anticancer …
The synthesized eight pyrido [2,3-d]pyrimidine derivatives have been structurally characterized and in vitro evaluated as novel lipoxygenase (LOX) inhibitors, with potential antioxidant and anticancer activity. The interaction with the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-Azobis(2-methylpropionamidine ...
Medicinal chemistry perspective of pyrido[2,3- d ]pyrimidines as ...
Pyrido [2,3- d]pyrimidine is an emerging scaffold in medicinal chemistry having a broad spectrum of activities, including antitumor, antibacterial, CNS depressive, anticonvulsant, and antipyretic activities.
Review on the Synthesis and Therapeutic Potential of Pyrido [2,3
2022年3月14日 — Pyrido [2,3-d]pyrimidine. The study starts with some interesting pyrido [2,3- d]pyrimidines. The first one is 5-methyl-6- ( [methyl (3,4,5-trimethoxyphenyl)amino]methyl)pyrido [2,3- d]pyrimidine-2,4-diamine (Table 1, entry 1) which has been described to have DHFR dihydrofolate as the target [6].
Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as ...
2023年2月28日 — This review will represent the complete medicinal and pharmacological profile of pyrido[2,3-d]pyrimidines as anticancer agents, and will help scientists to design new selective, effective and safe anticancer agents.
An overview on synthetic and pharmaceutical prospective of pyrido…
2020年9月18日 — Pyrido[2,3-d]pyrimidine, a fused hetero-bicyclic nucleus containing pyridine and pyrimidine rings has attained the momentary attention in the sphere of multicomponent synthetic protocol and medicinal chemist.
Design, Synthesis, and Bioevaluation of Pyrido [2,3-
2023年1月12日 — In the present study, we designed and synthesized a series of new SOS1 inhibitors with the pyrido[2,3-d]pyrimidin-7-one scaffold. One representative compound 8u showed comparable activities to the reported SOS1 inhibitor BI-3406 in both the biochemical assay and the 3-D cell growth inhibition assay.
Therapeutic potential of heterocyclic pyrimidine scaffolds
2018年4月4日 — The pyrido[2,3-d]pyrimidine derivatives were evaluated for their in vitro anti-proliferative activity against A431a, SNU638b, HCT116 and inhibition of CDK2-Cyclin A, CDK4/Cyclin D and EGFR enzyme.
Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical
2019年11月16日 — The present review covers the synthetic methods used for the synthesis of pyrido[2,3-d]pyrimidine-7(8H)-ones (2), both starting from a preformed pyrimidine ring or a pyridine ring, and the biomedical applications of such compounds.
Pyrimidine and fused pyrimidine derivatives as promising …
2020年10月29日 — Pyrimidine ring and its fused derivatives including pyrazolo[3,4-d]pyrimidine, pyrido[2,3-d]pyrimidine, quinazoline, and furo[2,3-d]pyrimidine derivatives have proved as great target molecules in medicinal chemistry and drug development. These scaffolds exerted their effect through inhibiting PKs which are considered as essential enzymes to ...