Syncytia formation during SARS-CoV-2 lung infection: a ... - Nature
2021年5月12日 · The new data obtained by Sun et al. provide critical information for understanding syncytia through deciphering the structure basis required for SARS-CoV-2 spike protein-mediated cell fusion ...
Syncytia formation by SARS‐CoV‐2‐infected cells - PMC
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms regulating the formation of these syncytia are not well understood. Here, we show ...
Syncytia formation during SARS-CoV-2 lung infection: a …
Sun et al. found that a type of CD45 positive cell structure presents in the syncytia of the COVID-19 patients. This could be a cell-in-cell structure. When human peripheral blood mononuclear cells were co-cultured with SARS-CoV-2 spike protein-induced syncytia, they could be engulfed by and die inside the syncytia, thus providing a possible ...
Syncytia formation by SARS-CoV-2-infected cells - PubMed
2020年12月1日 · Severe cases of COVID-19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms regulating the formation of these syncytia are not well understood. Here, we show that SARS-CoV-2-infected cells express the Spike p …
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
2021年4月7日 · Here we show that the lungs of patients with COVID-19 contain infected pneumocytes with abnormal morphology and frequent multinucleation. The generation of these syncytia results from...
High-throughput screening of genetic and cellular drivers of
2023年11月23日 · Mapping mutations and discovering cellular determinants that cause the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to induce infected cells to form syncytia...
Ultrastructural study confirms the formation of single and …
2023年5月19日 · SARS-CoV-2 was reported to induce cell fusions to form multinuclear syncytia that might facilitate viral replication, dissemination, immune evasion, and inflammatory responses. In this study, we have reported the types of cells involved in syncytia formation at different stages of COVID-19 disease through electron microscopy.
Differences in syncytia formation by SARS-CoV-2 variants modify …
2023年12月26日 · Critically, syncytia formation via the highly fusogenic Delta spike promotes cellular senescence and extracellular cytokine release in a TP53-dependent manner. We propose a model whereby differences in syncytia formation modify the activation of TP53-dependent senescence and inflammatory cytokine release (Figure 6 F).
The Mechanism and Consequences of SARS-CoV-2 Spike …
We summarize the clinical evidence for coronavirus-induced syncytia formation, examine the molecular determinants of S protein-mediated fusion, and discuss the antiviral innate immunity components that restrict cell–cell fusion.
Syncytia formation by SARS‐CoV‐2‐infected cells
2020年11月4日 · Our results show that SARS‐CoV‐2 pathological effects are modulated by cellular proteins that either inhibit or facilitate syncytia formation. Cells infected with SARS‐CoV‐2 fuse with neighboring cells to form syncytia. This process is accelerated by the TMPRSS2 protease and restricted by interferon‐induced transmembrane proteins (IFITMs).