The amino acid glutamine plays an unexpected role in erythropoiesis, the differentiation of erythroid progenitor cells into ...

Scientists at Northwestern and Case Western Reserve universities have developed the first polymer-based therapeutic for Huntington's disease, an incurable, debilitating illness that causes nerve cells ...

Studies support the idea of “polymers as therapeutics,” rather than polymers as carriers of drug molecules in the sense of ...

Patients with Huntington's disease have a genetic mutation that triggers proteins to misfold and clump together in the ... In studies in mice, the treatment successfully rescued neurons to reverse ...

GoTaq ® G2 Hot Start Taq Polymerase (M5122; Promega) was utilized for PCR to screen for InDels/mutations in the region of interest. The resulting PCR amplicon underwent purification using either ...

When the gene that codes for EGFR has a mutation, it affects the way this protein works, causing cancer. There are many types of EGFR mutations. The EGFR protein lives in the cell membrane with ...

Cheng explains. This becomes even more complicated when disease-causing DNA mutations are introduced into the mix. Some genes can be mutated in many ways to cause the same disease, meaning one ...

Oncogenic mutations often involve single nucleotide substitutions at specific hotspots, leading to hyperactive or gain-of-function variants. Tumor suppressor mutations typically involve indels ...

Researchers have discovered key mutations in certain cancer cells that make them resistant to WRN inhibitors, a new class of anti-cancer drugs. The yet-to-be-published findings are presented on ...