Exocytosis is the process by which cytoplasmic secretory vesicles fuse with the cellular membrane, releasing contents to the extracellular space. The extrusion of large extracellular vesicles is ...

In neurodegenerative diseases, microglia can help or harm the brain. In the October 3 Journal of Clinical Investigation, scientists led by Ilia Baskakov at the University of Maryland School of ...

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, significantly ...

Transient receptor potential mucolipin 1 (TRPML1) functions as a lysosomal ion channel whose variants are associated with lysosomal storage disorder mucolipidosis type IV. This important report ...

Cryptococcal meningitis (CM) is the leading cause of fungal meningitis in humans worldwide, with the largest disease burden reported in Africa (1). The majority of CM cases are caused by members of ...

In glioma, microglia and infiltrating macrophages are exposed to factors that force them to produce cytokines and chemokines, which contribute to tumor growth and to maintaining a pro-tumorigenic, ...