Neuroblastoma (NB) is a common tumor of the peripheral sympathetic nervous system in young children, a subset of which have amplified the MYCN oncogene and have a particularly poor prognosis 2.
To characterize the action of the new peripheral nervous system component, the researchers used mice genetically modified to not express neuropeptide Y in the sympathetic nervous system.
While the central nervous system comprises neurons in the brain and spinal cord, the sympathetic, or peripheral, autonomic nervous system consists of neurons in ganglia (groups or clusters ...