Co. Ltd. has divulged compounds acting as histone deacetylase 1 (HDAC1) and/or 2 (HDAC2) inhibitors reported to be useful for the treatment of cancer.

Calcitonin gene-related peptide (CGRP) inhibitors are a relatively new type of medication approved by the Food and Drug Administration (FDA) to treat and prevent migraines with or without aura. They ...

HDAC, CDK4/6 inhibitors, DNA damage repair inhibitors, and immunotherapy with ICIs is mechanistically reliable and has some application prospects. In summary, the above inhibitor-targeted therapies ...

1Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China. 2Key Laboratory of Xiamen for Diagnosis ...

In the phase 1b/2 trial, investigators assessed the combination of HBI 8000 with nivolumab for the treatment of patients with advanced melanoma, kidney cancer, and non–small cell lung cancer ...

This study reports a valuable finding for the treatment of colorectal cancer (CRC), as the authors demonstrated that the enzyme CPT1A plays a significant role in the response to radiotherapy in CRC ...

People with cancer now have a multitude of treatment options beyond chemotherapy and radiation. One such advanced approach, called immune checkpoint inhibitor therapy, enables immune cells called T ...

The phase 3 trial found adding the TIGIT candidate tiragolumab to Roche's approved checkpoint inhibitor had no effect on overall survival (OS) in non-small cell lung cancer (NSCLC). Investigators ...

"Immune checkpoint inhibitor therapies have revolutionized cancer treatment by allowing T cells to attack tumors and cancer cells more effectively. But this hasn't been without side effects—one ...

Janus kinase (JAK) inhibitors are a group of medications that can treat various types of arthritis, including rheumatoid arthritis (RA), cancer, dermatological conditions like atopic dermatitis and ...