1Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China. 2Key Laboratory of Xiamen for Diagnosis ...

Janus kinase (JAK) inhibitors are a group of medications that can treat various types of arthritis, including rheumatoid arthritis (RA), cancer, dermatological conditions like atopic dermatitis and ...

Alamar blue was used to assay cell number following three days of drug exposure. Cell numbers were reduced by both drugs in both cell lines (Figure 2).

commercially available assay is myChoice CDx developed by Myriad, which calculates HRD score according to loss of heterozygosity (LOH), telomeric allelic imbalance (TAI), and large-scale state ...

Also in Recursion’s rare disease pipeline: • REC-2282, a pan-HDAC inhibitor being developed to treat Neurofibromatosis Type 2. Results from a six-month progression-free survival (PFS6 ...

Immune profiling by mass cytometry (CyTOF) analysis shows that selective class I HDAC inhibitor (HDACi) Entinostat (ENT) significantly enriches inflammatory MDMs in E0771 murine mammary tumor BrM ...

Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China ...

Molecular Nutrition Group, Department of Nutrition, Dietetics and Food, Monash University, Victorian Heart Institute, Victoria Heart Hospital, 631 Blackburn Road, Clayton, VIC 3168, Australia ...

The roles of FFAR activation, HDAC inhibition, protein (histone) propionylation, and anti-inflammatory signaling in propionate-mediated effects should be further understood. In addition, the causes ...

Image Credit: Promega Corporation The NanoBRET ™ TE HDAC1 Assay was used in a study looking at isozyme-specific engagement and binding kinetics for a histone deacetylase (HDAC) inhibitor panel.