Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850, United States ...

Another important structural feature of the UCH family is a hydrophobic β-sheet core containing a conserved catalytic triad of cysteine, histidine, and aspartate wrapped by several α-helices and a ...

The conserved R47 couples substrate binding to the conformational changes in the protein. Deprotonation of D46 opens the intracellular gate and permits galactonate dissociation, either protonated or ...

Carbonic anhydrases (CAs) are widespread enzymes in bacteria, archaea and eukaryotes, and catalyze a crucially important physiological reaction: the hydration of carbon dioxide to bicarbonate and ...