Neural tube defects (NTDs) resulting from loss of Tet1 are refractory to rescue by folic acid (FA) supplementation across strains. Both excess and deprivation of FA alter DNA hypermethylation in Tet1 ...

SOX-OCT binding site and CTCF binding site 3 in H19-ICR are the sequences in which mutations cause H19-ICR hypermethylation leading to Beckwith-Wiedemann syndrome-like overgrowth. DNA methylation ...

As an oncometabolite, R-2-HG induces malignant transformation of glial progenitor cells by altering the chromatin structure (through broad DNA and histone hypermethylation) and disrupting the ...

Andrew Feinberg, the Bloomberg Distinguished Professor of Biomedical Engineering at Johns Hopkins University, has been ...

Stephen Baylin, Andrew Feinberg honored for their pioneering research in epigenetics along with Van Andel Institute's Peter ...

Skeletal muscle tissue demonstrates global hypermethylation with aging. However, methylome changes across the time-course of ...

DNA methylation is a fundamental modification characterized by the addition of a ... By analyzing 571 PTC samples from The Cancer Genome Atlas (TCGA), the researchers found that patients with TERT ...

This study would be of interest to biologists in the fields of epigenetics and metabolism. Maternal obesity has deleterious effects on the process of establishing oocyte DNA methylation; yet the ...

CNET's experts have pitted the best DNA testing kits against each other to help you pick the right one for your needs. Shelby Brown Editor II Shelby Brown (she/her/hers) is an editor for CNET's ...

5-aza-2′-deoxycytidine was used to inhibit DNA methyltransferases (Dnmts) in cultured fibroblasts and in the mouse ... were hypermethylated in fibroblasts and peripheral blood mononuclear cells of ...