Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...

To join the ICR you’ll be a talented scientist looking for the next step after your initial postdoctoral studies. You’ll be ready to start leading a team independently under the mentorship of a ...

The story so far: The 2024 Nobel Prize for chemistry was jointly awarded to David Baker for his work on computational protein design and to Demis Hassabis and John Jumper for developing ...

Development of methods for time-resolved structural studies using synchrotron and XFEL radiation, applied to study membrane-bound energy converting enzymes of the cell. Structure-based drug design to ...

This important study by Bi and colleagues employed a clever genetics screen to uncover the role of the GidB rRNA methylase in translation fidelity, under certain conditions, in Mycobacterium smegmatis ...

Compared to the sole use of amino acid sequences or protein structure data, the proposed method took a multi-level feature fusion ... Therefore, 5-fold cross-validation was used to conduct ablation ...

Then, another molecule called a ribosome reads the mRNA, translating it into protein. But this step has ... and because of their simple genetic structure, provided the team with the ideal host ...

"Think of it like a super detailed map showing how different proteins in a cell are connected," Coskun said. The iseqPLA can examine 47 protein interactions in a single sample, which saves a lot of ...

Several theories regarding the pathogenesis of protein contact dermatitis have been proposed. First, it is possible that protein contact dermatitis is primarily a type I immediate hypersensitivity ...

More information: Shuangyi Cai et al, Spatially resolved subcellular protein–protein interactomics in drug-perturbed lung-cancer cultures and tissues, Nature Biomedical Engineering (2024). DOI ...

Researchers have developed an AI-based protein design tool known as EVOLVEPro ... but here we saw improvements to both." Studies like this one show the promise of advances in gene and cell ...