Hu Zheng from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, along with their ...

As originally formulated, the CSC model stated that, similarly to normal tissues, tumors are organized in a pyramidal manner, irrespective of whether or not cancers arise from the malignant ...

Researchers led by Prof. HU Zheng from SIAT, uncovered a polyclonal origin of tumors, challenging the traditional clonal evolution theory. Using a DNA barcoding system in mouse models and genomic ...

Clonal evolution, which is the genetic adaptation of cancer cells to treatment and environmental pressures, remains a key challenge in oncology. Nevertheless, recent technological advances have ...

Researchers have developed a three-dimensional mathematical model of prostate cancer. The model depicts various processes, including tumour growth, genetic evolution and tumour cell competition.

The authors thank AM Edlisca and T Merlino for their technical assistance. The authors apologize to all our colleagues whose important work could not be directly cited. Cancer stem cell model ...

A team led by Dr. Yuri Tolkach at the University of Cologne's Faculty of Medicine and University Hospital Cologne has ...