This interesting study presents valuable information on how human cytomegalovirus (HCMV) infection disrupts the activity of the TEAD1 transcription factor, leading to widespread chromatin alterations.

Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chromatin buffers latent topological stress. During the antigen-dependent phase ...

Using silencer-seq, the Stark lab identified 800+ silencers and the transcription factor Saft in fruit flies, enhancing our ...

Thousands of scientists and plant breeders have since used that genome in their own research on the genetic makeup underlying ...

Findings announced by Israeli researchers on Monday may reshape science’s understanding of how fasting impacts metabolic ...

Depending on chemical markers placed on these histones, the chromatin can be wound tightly — preventing transcription factors from binding — or loosely, making it accessible for generating mRNA copies ...

Fasting is an integral part of everyday life for millions of people worldwide, often practiced for religious or spiritual ...

In the post-division interphase stage of the cell cycle, the chromatin’s shape and location impact gene expression by bringing distant DNA regions into close contact. For example, enhancers (DNA ...

Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London W12 0BZ, U.K. The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K. Institute of ...