Scientists have long observed a connection between opioid use disorder (OUD) and chronic pain, but the exact reasons behind ...

However, the presence of central sensitization may help clinicians to work out what treatments will work best. The immune system and pain thresholds The immune system can influence nerve signals ...

Nearly 30% of women with deep endometriosis experience reduced pleasure sensitivity (anhedonia), linked to chronic pelvic ...

Complex regional pain syndrome is a chronic ... 2 A drug that induces peripheral sensitization of somatic or sympathetic nerves and/or central sensitization of brain systems could potentiate ...

Most scientists accept that it involves activation and sensitization of the ... sensory peripheral projections to the pain-producing dura mater, and a central projection to the trigeminal nucleus ...