Fred Hutch researchers have done pioneering work in the areas of gene regulation, chromatin organization and cell cycle state, including quiescence. Gene expression is important because a specific ...

In addition, gene expression changes can lead to changes in an entire organism, such as molting in insects. In Drosophila, for example, the molting process is regulated by levels of a hormone ...

As trp levels increase ... changes in gene expression. In the case of the trp operon, the ligand tryptophan is required for the repressor to work (repressible negative regulation).

In this way, the expression of a target gene can be boosted more than 1,000-fold. "This regulation at the RNA level brings ...