Fred Hutch researchers have done pioneering work in the areas of gene regulation, chromatin organization and cell cycle state, including quiescence. Gene expression is important because a specific ...

As trp levels increase ... changes in gene expression. In the case of the trp operon, the ligand tryptophan is required for the repressor to work (repressible negative regulation).

Studies of transcription and promoter function in transgenic plants will be covered as well as manipulating the targeting of gene products to different organelles, particularly in respect of ...

Sometimes, the stability of the mRNA molecule itself affects levels of eukaryotic gene expression. Once created, mRNA does not last forever; stable mRNAs will last long enough to be translated ...

In this way, the expression of a target gene can be boosted more than 1,000-fold. "This regulation at the RNA level brings ...

Along our journey, we shall reveal basic principles of gene regulation. We aim to exploit the new knowledge to help devise novel treatments of many diseases that stem from misregulated gene ...