Fred Hutch researchers have done pioneering work in the areas of gene regulation, chromatin organization and cell cycle state, including quiescence. Gene expression is important because a specific ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

As trp levels increase ... changes in gene expression. In the case of the trp operon, the ligand tryptophan is required for the repressor to work (repressible negative regulation).

In this way, the expression of a target gene can be boosted more than 1,000-fold. "This regulation at the RNA level brings ...