With increasing numbers of short hairpin RNA (shRNA) and short interfering ... leading to both a deeper insight regarding the basic mechanism of RNAi and better siRNA tools. And Buchholz thinks ...

A new technology, mvGPT, is capable of precisely editing genes, activating gene expression, and repressing genes all at the ...

New research identifies key cellular mechanism driving Alzheimer's disease. ScienceDaily . Retrieved January 13, 2025 from www.sciencedaily.com / releases / 2024 / 12 / 241223135051.htm ...

Objective Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined. Sphingolipids and free cholesterol (FC) ...

Researchers at the Medical University of South Carolina have discovered a key genetic mechanism that could lead to RNA-based therapies for psychiatric disorders triggered by emotional experiences.

It operates via a molecular "cut and paste" mechanism driven by special proteins, known as recombinases. The integron system has been researched a lot. Some bacteria gain new resistance very fast ...

From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...

Background and objective Gastric cancer (GC) remains a prevalent and preventable disease, yet accurate early diagnostic ...

Short hairpin RNA (shRNA) against human GPX4 (NM_002085, shGPX4), shRNA against no known target in the human gene which was used as the negative control (shNeg), and transfection reagent (REVG006‐1) ...

Overall this paper may offer insight into mechanisms by which BRCA1 deficiency fuels breast tumorigenesis ... For ELF3 knockdown by lentivirus in SUM149PT, shELF3 and shCtrl sequence was subcloned ...

Jan. 7, 2025 — In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem ...