highlights macrophage tolerance in TLR signaling, crucial for adapting to chronic endotoxin exposure and mitigating ... s review underscores TLRs’ significant role in inflammatory bowel disease (IBD), ...

The tumor microenvironment (TME) is a complex and dynamic entity that encompasses not only the tumor cells but also an array of non-cancerous cells, signaling molecules, and the extracellular matrix .

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

Gregory Reeves has led this discovery of the highly conserved Bone Morphogenetic Protein (BMP) Signaling Pathway, which operates in all animals and can achieve a variety of outcomes depending on ...

TLR antagonists are being investigated ... A recent study showed that the TLR4 signalling pathway can mediate such a signal 38. Individuals with breast cancer who carried a TLR4 loss-of-function ...

Vitamin D boosts the ability of macrophages to kill Mycobacterium tuberculosis via the vitamin D–cathelicidin pathway ... but requires TLR activation and IL-1β. The importance of additional ...

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...

Despite promising Phase II data, there was no difference in overall survival between the patients who received Canvaxin and the patients who received placebo in the randomized Phase III trial of ...

This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the ...

IND cleared by FDA and dosing in the Phase 1 clinical trial initiated, with data expected in the first half of 2025Sanofi ...

A father and daughter team based in the U.S. have decoded a mock "alien signal" beamed from ESA's ExoMars Trace Gas Orbiter a year ago — but the meaning of the extraterrestrial message remains a ...