Here, the authors show that tumor cell-intrinsic ATP6V0A1 drives RABGEF1-dependent cholesterol absorption and thus triggers paracrine TGF-β1/SMAD3 signaling to inactive memory CD8 + T cells in CRC.

Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and development. The study is published in the journal Nature Communications.

T cells are a type of white blood cell that is central to your immune defense. There are four types which serve different functions: This article will guide you through how CD4 and CD8 cells interact, ...

Data were summarized with the search of 'colorectal' and 'antibody' as of August 2012 at ClinicalTrials.gov [202]. EGFR: EGF receptor; mAb: Monoclonal antibody; VEGFR: VEGF receptor. The authors ...

TGF-β介导TIGIT+Treg和CD226+CD8+T细胞间相互作用参与T1D进展及缓解的免疫扰动模型（图源自Nature Communications） 在此背景下，该研究通过单细胞转录组测序 ...

Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of ...