and an understanding of how protein kinases function in vivo is therefore of central importance to cell biology. Newly developed protein-kinase inhibitors provide powerful tools for understanding ...

Laura Bonetta reports. Phosphorylation is the main device a cell uses to control the function of its proteins. The responsible enzymes, protein kinases, regulate a myriad of processes from cell ...

Varjosalo Lab's longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate ...

Protein tyrosine kinases and protein tyrosine phosphatases coordinate to maintain a protein phospohorylation balance required for normal cell function. If this balance is disrupted, the outcome may be ...

The three-dimensional shape of a protein determines its function. This is because proteins form attachments and interact with many other molecules and structures inside organisms. The shape of a ...

This leads to impaired function of the mitochondria ... muscles that metabolizes and converts creatine—a protein called ...