Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...

The protein, proliferating cell nuclear antigen (PCNA), was once thought too challenging to aim targeted therapies at. PCNA in its mutated form encourages tumours to grow by aiding DNA replication ...

Regulation of PCNA ubiquitination is required for initiating ... normally excluded DNA repair protein enter, causing aberrant rDNA recombination, genome instability and death.