NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991 ... the substrate and the inhibitor used in the inhibition experiments. Selectivity of NSAIDs is currently based ...

Use of nonsteroidal anti-inflammatory drugs (NSAIDs), especially over-the-counter formulations, and certain other drug classes are among the risk factors for community-acquired acute kidney injury (CA ...

NSAIDs -- But Not COX-2s -- Inhibit ... This newly identified and unique drug-drug interaction does not extend to the COX-2-specific inhibitors, such as rofecoxib (Vioxx -- Merck), as they have ...

Received 693 new patient start forms for FILSPARI® (sparsentan) in the fourth quarter of 2024; approximately $50 million in preliminary net ...

Traditional NSAIDs like ibuprofen work by inhibiting enzymes called cyclooxygenase (COX) 1 and 2. By blocking these enzymes, NSAIDs prevent the formation of compounds called prostaglandins ...

In 2024, there were numerous trials and a few regulatory moves related to advancements in lipid management for the prevention of major adverse CV events.

TDM-180935 is a topical Janus kinase (JAK)-1/tyrosine kinase (TYK)-2 inhibitor ointment that has previously completed a phase 1 study that showed excellent toleration and minimal systemic ...