1C). Pseudotime analysis reveals that increased pseudotime is correlated with increased expression of Cthrc1 (Fig. 1D). Conclusion: Our comprehensive single-cell atlas of cardiac fibroblasts after MI ...

The primary pathological features of fibrotic diseases include recurrent damage to normal cells and the abnormal activation of fibroblasts, leading to excessive deposition of extracellular matrix and ...

Objectives Myofibroblasts are key effector cells in the extracellular matrix remodelling of systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of fibroblast ...

Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...

The fibrotic response consists of four stages: organ damage, effector cell activation, increased production of extracellular matrix (ECM), and dynamic deposition of connective tissue. Among these, the ...

PGC-1α induces myofibroblast activation and collagen release ... Fibroblasts from patients with SSc are aberrantly activated and release excessive amounts of extracellular matrix (ECM).1 The ...

and small molecule libraries to identify novel gene and molecular regulators of myofibroblast function. Performing high-content image analysis helps the research team assess functional outcomes, ...

Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an ...

Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in bone biology and hematopoiesis, respectively. The role of ...