U-II was found to increase afterload and reduce myocardial contractility. Its effect at high concentrations is best rationalized by myocardial ischemia. Using the calculations of Sunagawa et al.

Specifically, before revascularization, 804 of 2,093 myocardial segments analyzed (38%) had abnormal contractility, and 694 segments (33%) had some areas of hyperenhancement. Among all 804 ...

Peptides have emerged as a focal point in molecular and biological research, providing a promising avenue for understanding ...

Clinical feature in adults Transient depression of myocardial contractility; myocardial necrosis (cTnT elevation); arrhythmia Dilated cardiomyopathy; arrhythmia Dilated cardiomyopathy; arrhythmia ...

Istaroxime is designed as a positive inotropic agent that increases myocardial contractility through inhibition of Na+/K+- ATPase with a complimentary mechanism that facilitates myocardial ...