Promoting tumour apoptosis, diminishing necrosis and enhancing acute inflammation in the tumour microenvironment are novel treatment strategies. Perhaps the most tractable target for therapy is ...

Tumour Necrosis Factor TNF is crucial for defence but can drive chronic inflammation linked to arthritis and autoimmune diseases when overproduced ...

结果发现，上皮细胞和髓系细胞是决定治疗成功的关键，上皮细胞往往排列在肠道表面，比如称之为杯状细胞的特定上皮细胞，从而就会产生凝胶样粘蛋白并保护机体免受肠道细菌的侵袭；此外，他们还发现，因抗肿瘤坏死因子疗法获益的患者往往拥有更多杯状细胞且能表现出高水平 ...

Discover the impact of hypereosinophilia on heart health, focusing on eosinophilic heart disease (EHD) and its mechanisms.

More information: Tom Thomas et al, A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease, Nature Immunology (2024). DOI: 10.1038/s41590-024-01994-8 ...

A recent meta-analysis published in JAMA Neurology has revealed that tumor necrosis factor (TNF) inhibitors, widely used in treating autoimmune diseases, may increase the risk of ...