LMU molecular biologist Gunnar Schotta decodes the epigenetic silencing of problematic retroviral gene sequences.

Gene clusters 1 and 2 tend to bind e1a early ... continue to be acetylated at this histone residue and were strongly induced. This acetylation pattern was echoed by the presence of the p300 ...

For instance, some repressors bind near the start of mRNA production for an entire operon, or cluster of coregulated ... When a specific gene is tightly bound with histone, that gene is "off." ...