Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850, United States ...

The conserved R47 couples substrate binding to the conformational changes in the protein. Deprotonation of D46 opens the intracellular gate and permits galactonate dissociation, either protonated or ...

The formation of a favourable 6-membered chelate ring, involving the deprotonated peptide nitrogen of histidine, rather than a 7-membered ring, supports the view that metal ion coordination ...

To identify the counterion and clarify the proton-mediated gating mechanism of GtACR1, we investigate the Glu68 and Asp234 mutant proteins (E68Q, E68D, D234N, D234E, and E68Q/D234N) expressed in ...

KCa3.1 is unique among these four channels in that activation requires, in addition to calcium, phosphorylation of a single histidine residue (His358) in the cytoplasmic region, by nucleoside ...