Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters ... Recombinase A; RecBCD, ...

Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation).

Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

"Our biochemical analysis with purified BRCA1 protein helps illuminate ... mechanism (homologous recombination, HR). BRCA1 acts to channel DNA breaks into HR for repair, Burma said.

Here the authors identify an important role of 53BP1 in suppressing mutagenic BIR, providing insights into DSB repair ... the DNA-cleaving ensembles that initiate meiotic recombination, elucidate ...

Research led by The University of Texas Health Science Center at San Antonio shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes ...

"Our biochemical analysis with purified BRCA1 protein helps illuminate ... mechanism (homologous recombination, HR). BRCA1 acts to channel DNA breaks into HR for repair, Burma said.

This is because, like DNA, RNA can carry genetic information, but, like a protein, it can also act as an enzyme, initiating or accelerating reactions. A novel discovery in the field of pancreatic ...

In mammalian cells, two primary mechanisms for DSB repair predominate: homologous recombination and NHEJ (Scully et al ... followed by the subsequent recruitment of the catalytic subunit DNA-dependent ...

A new study conducted in roundworms finds that a common plastic ingredient causes breaks in DNA strands, resulting in egg cells with the wrong number of chromosomes. A new study conducted in ...