Skeletal muscle tissue demonstrates global hypermethylation with aging. However, methylome changes across the time-course of ...

the most frequently examined and best understood is DNA methylation (DNAm). DNAm occurs by the addition of a methyl group onto a cytosine-phosphate-guanine base pairing, which can decrease or inhibit ...

Hypermethylation of CpG islands can cause tumors by shutting off tumor-suppressor genes. In fact, these types of changes may be more common in human cancer than DNA sequence mutations (Figure 2).

Stephen Baylin, Andrew Feinberg honored for their pioneering research in epigenetics along with Van Andel Institute's Peter ...

As an oncometabolite, R-2-HG induces malignant transformation of glial progenitor cells by altering the chromatin structure (through broad DNA and histone hypermethylation) and disrupting the ...